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Numerous studies have shown that the upregulation of NOXs in vascular tissues and cell types such as endothelial cells, smooth muscle cells, fibroblasts, and others plays a key role in atherogenesis by promoting endothelial dysfunction and vascular inflammation

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And, quite obviously, not smoking

The Japanese were particularly surprised to see the Portuguese smoking pipes and spitting out smoke and would have exclaimed: The Southern Barbarians have a fire in their belly! Tobacco was quickly adopted by the Japanese people by the end of the sixteenth century, the Kerisu or Smoking Pipes were used as the only way to smoke tobacco in Japan and it would remain that way for the next three centuries, until the Meiji Restoration (1868), when cigarettes arrived in Japan and became very popular

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