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Tolerance (neuroadaptation) is commonly attributed to the downregulation of nicotinic receptors in a compensatory response to overactivation to maintain homeostasis

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High levels of THC are associated with increased anxiety, panic, impaired thinking, and a higher risk of dependence

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This increases the risk of: Ischemic Stroke (due to clots) Hemorrhagic Stroke (due to bleeding) Aneurysm rupture (a life-threatening brain bleed) Ive seen lives shattered by sudden aneurysm rupture in patients with no prior symptoms, but a history of regular smoking