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Model 2 was adjusted for age, sex, body mass index, household income, area of residence, duration of smoking, previous pack-years of smoking, alcohol consumption, regular physical activity, comorbidities (hypertension, dyslipidemia, CKD, and pulmonary diseases (defined as any of ILD, asthma, or COPD)

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At this later time point, the majority of alternatively regulated pathways indicated the development of a pro-carcinogenesis phenotype that complemented observations in the adjacent dpHBECs

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