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22 In addition, deubiquitinating enzymes (DUBs) regulate mitophagy by deubiquitinating Parkin or its targets on the mitochondrial, and Parkin can mediate nuclear translocation of transcript factor EB (TFEB), thereby upregulating the expression of genes associated with lysosome biogenesis (Fig

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In a TV interview in 1996, the president of the American Medical Association, Lonnie Bristow, famously claimed, We were duped. This is in spite of the AMA having accepted cigarette ads in its journal from the early-1930s to the mid-1950s, the same time period when the epidemiological and pathological research showing the association between smoking and disease was being published