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Biological pathway enrichment analyses carried out in ConsensusPathDB [44] using the genes implicated by the eQTL databases (Table 2) and/or a coding SNVs (i.e., PJA1 , GPR101 ) showed that the (i) pyrimidine metabolism and (ii) activation of nicotinic acetylcholine receptors pathways are enriched for these smoking behaviour associated genes (false discovery rate 0.8) were associated with years of educational attainment [37] (rs2292239, rs3001723 ( P C polymorphism in microRNA target sites contributes to lung cancer susceptibility

The partial nicotine agonist varenicline has been licensed in several countries for smoking cessation, based on several randomized controlled studies against placebo, bupropion and nicotine replacement patches (77)

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