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Each 2-s puff of an e-cigarette delivers 6.25 10 10 ultrafine particles into the airways, raising concerns about long-term particulate exposure in adolescent users (38)

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Smokers' impaired airway barriers and compromised macrophage function mean they are significantly more vulnerable during these peaks experiencing higher infection rates, more severe illness, and longer recovery times than non-smoking population members under identical exposure conditions

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