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Proposed explanations include the lower body mass index of smokers, survival and selection bias inherent in cross-sectional designs, and possible chronic vasodilatory effects of carbon monoxide exposure

If heavily using marijuana is causing the orbitofrontal cortex to shrink, smokers could be developing thicker cross-brain connections as a means of compensating, the scientists write in their paper

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Further evidence in terms of the efficacy of NRTs, ideally from placebo-controlled RCTs with high rates of compliance with NRT treatment, is needed in order to fully understand the role of NRT in supporting cessation during pregnancy 1

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