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12,16 CLINICAL PRACTICE GUIDELINES The Public Health Service (PHS) has provided Clinical Practice Guidelines for Treating Tobacco Use and Dependence, which highlight the Five As Approach used by health care professionals

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As previously shown, MPTP reduced tyrosine hydroxylase immunoreactivity and DA levels, and increased several markers of neuroinflammation such as microglial activation, and the expression of the inducible nitric oxide synthase, metallothionein-III, heme oxygenase 1