the american psychiatric association defines tobacco use disorder as Prospective Associations Between Product and Mental Health and Substance Use Problems Among U.S. Adolescents and Adults Associations of cigarette smoking with

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(If an agent is to be used, the applicant must state it will comply with T.D.'s 55027(2) and 55207(1), and 191.9, as applicable, and that its agent will submit a letter of notification of intent to operate under the general manufacturing drawback ruling for agents (see 191.7 and Appendix A), or an application for a specific manufacturing drawback ruling (see 191.8 and this Appendix B).) 3