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The cancer mortality rates of four subtypes among the youngest male and female age groups (0-29 years old) were small, and these age groups were thus excluded from the age-specific analysis

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By contrast, tobacco consumption significantly altered gut microbiota composition, with current smokers showing increased Bacteroidetes and decreased Firmicutes and Proteobacteria compared to never-smokers

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Health Effects of Smokeless Tobacco Products (PDF) (Report)