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Smoking contributes to heart disease, and use of smoked or smokeless tobacco can cause 12+ types of cancer and makes up ~40% of cancer diagnoses

And while analysts say the firm's profit margins on its products are well above traditional cigarettes, that's at least in part because they are free of the kinds of taxes levied on traditional tobacco

Willeit M, Ginovart N, Graff A, Rusjan P, Mizrahi R, Seeman P et al (2006) In vivo competition of endogenous dopamine with the novel D2/3 receptor agonist-radioligand [11C]-(+)-PHNO

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