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Recently, a study that utilized the PNE ADHD mouse model found that administration of MPH (1 mg/kg) restored the behavioral impairments and neuroplasticity changes in the AMPAR subunit composition and distribution while restoring the density and maturation of dendritic spines of the hippocampal pyramidal neurons (Figure 3) [83]

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Although we recognize that data limitations may affect the precision of some of the numbers we present, there is sufficient evidence in total to support our audit findings, conclusions, and recommendations

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[PubMed: 2609346] Sopori ML, Gairola CC, DeLucia AJ, Bryant LR, Cherian S