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A diferencia de la hormona de crecimiento completa, el AOD-9604 conserva nicamente el dominio implicado en el metabolismo de las grasas y carece de la estructura necesaria para unirse al receptor de GH, por lo que no estimula la produccin de IGF-1 ni el crecimiento celular

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In the aforementioned study from our group, adult mice with partial IGF-1 also displayed decreased expression of genes involved in lipid metabolism (ATP-citrate lyase, acetyl-CoA acyltransferase 1B, acetyl-CoA acetyltransferase 1) and cholesterol synthesis and transport (Both HMG-CoA reductase and synthase, LDL-related protein 1, proprotein convertase subtilisin/Kesin type 9), resulting in dyslipidaemia

Thus, the dual advantage of consuming fewer calories while burning fats as an energy source may contribute to the lipotropic actions of choline