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We then stratified on mothers reported smoking status during pregnancy and ran a univariable regression and a multivariable regression accounting for year of birth, sex and the first ten principal components

There is a need for continued research to develop or adapt and implement novel, low-cost cessation interventions in LMICs

Over time, the brain adapts by: Reducing natural dopamine production Requiring higher doses of nicotine to feel the same effects Increasing cravings and irritability without nicotine The National Institute on Drug Abuse (NIDA) reports that nicotine produces addiction-related brain changes comparable to other highly addictive substances, helping explain why quitting can feel difficult even after relatively short-term use

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