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KD lowers insulin, causing a decrease in IGF-1, which consequently leads to an increase in IGFBP-3 (191)

However, some local side effects such as mouth irritation, nausea, and hiccup were seen by mouth spray formulation containing 1 mg nicotine per actuation (72)

Supplemental material Ethics statements Patient consent for publication Acknowledgments The authors thank the anonymous reviewers and the editor for their constructive comments and suggestions that made this manuscript more concise and informative

Smoking affects the immune system, making smokers more likely to develop bacterial infection