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2023;75(6):872-878 Alfredsson L

Elucidating compound mechanism of action by network perturbation analysis

This could include: 1) More sophisticated mathematical models to support the peritoneal membrane function testing, such as detailed descriptions of icodextrin, macromolecular or trans-capillary aspects of peritoneal membrane function, 2) Peritoneal Equilibration Test (PET), which measures the solute and water transfer across the PM to semi-quantitatively, a non-invasive method, assess PD performance, that should be established in the clinics, 3) Better biomarkers need to be validated and used to create reliable models of prognosis, 4) Omics-based biomarkers in PD effluent of long term PD patients have the potential to predict or diagnose peritoneal membrane dysfunction, enabling the establishment of reliable early prognostic tools and, possibly, the discovery of novel therapeutic targets, 5) Peritoneal microbiota needs to be investigated in fibrogenesis, to elucidate the molecular mechanisms developmental pathways of peritoneal fibrosis, Testing treatments that protect the peritoneal membrane could include: 1) New therapies use antibodies or proteins to change the expression of these molecules that cause inflammation, which can help stop the PMCs from transforming into fibrous tissue

2011;6:e26575

Mitochondrial and metabolic alterations in cancer cells

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