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P2X3 receptors are also highly responsive to neurotrophic factors such as NGF and CGRP, both of which are elevated in inflamed skin and capable of enhancing P2X3 expression while lowering the threshold for neuronal activation, thereby promoting a state of hyperexcitability (108)

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For example, in the event that menthol is prohibited in cigarettes during the course of this project, we will still be able to provide novel data to inform the regulation of flavors in e-cigarettes which is an important area of study in tobacco regulatory science