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It is well documented that a significant positive association between psoriasis and smoking exists in a dose-dependent manner

doi: 10.1016/j.amjmed.2003.07.018

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5,40,86 Consequently, future studies should combine exposure history with single-cell transcriptomics, spatial transcriptomics, and immune phenotyping of synovial fluid and blood, so that hypotheses about macrophages, inflammasomes, and Th17/Treg imbalance can be tested directly in patient tissues rather than inferred from other organs

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