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Direct lung inhales (DL) typically result in larger vapor volume and higher nicotine intake compared to mouth-to-lung (MTL) inhales

Effects Nicotine reaches the brain in less than ten seconds upon first inhalation from cigarette smoke and the central nervous system in less than five minutes

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The boxes, some hand-painted with landscape scenes, some made from gold, porcelain or stone, contained a small amount of tobacco, which users would sniff, or snuff, throughout the day