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However, the impacts of integrating different cohorts on current study findings are expected to be trivial because the data for three cohorts were collected using standardized procedures 21

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The studies analyzed consistently highlight adolescence as a critical period of neurobiological maturationparticularly within the prefrontal cortex and limbic regions that regulate cognition, emotion, and decision-makingduring which nicotine exposure may confer heightened vulnerability ( Nicotine acts on nicotinic acetylcholine receptors, affecting neurotransmission and synaptic plasticity

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These harmful substances then become trapped inside the charcoal grains porous, cave-like indentations and tunnels