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Understanding these differences and being informed about the potential risks and benefits is crucial, especially for those considering a switch from traditional cigarettes to vapes

While changes in protein expression for cisplatin transporters were consistent across cell lines, at the mRNA level, the effect of e-cigarette aerosol in the expression of cisplatin transporters varied by cell line, with for example ATP7A showing an increase in all cell lines tested and ABCG2 , ABCC1, and ABCC2 showing variable expression across cell lines

Additionally, cross-country comparative studies and international collaborations, particularly with countries implementing similar tobacco control strategies, may provide valuable insights and support the development of scalable solutions tailored to diverse contexts.

"There is a need for continued surveillance of e-liquids, particularly tobacco flavored, which may be manipulated to circumvent policies on flavor use."