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Although these researchers also found no significant differences in bronchial microbiome between stability and exacerbation using 16S rRNA sequencing and shotgun metagenomic sequencing, functional metabolic capabilities showed significant changes in several pathways, indicating specific changes in the lung microbiome in the progression of COPD [82]

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The female end-user segment accounted for 37.7% of global low tar cigarette revenues in 2025 and is projected to grow at a faster CAGR of 5.0% through 2034 compared to 3.7% for male consumers

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