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Yet setting that goal was also a tacit acknowledgement that a national smoke-free law, which would cover 100% of the population and was arguably the treatys most important component, was dead

TPM, total particulate matter Editors' Summary Background The tobacco industry in the United States has recognized that regulation of its products was inevitable as early as 1963 and devoted increasing attention to the likelihood of regulation by the US Food and Drug Administration in the mid-1990s, which finally became law in 2009

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Inhalation of cigarette smoke, by either active or passive smokers, increases the levels of carboxyhaemoglobin (COHb) in the blood, decreasing the supply of O2 to the tissues

Nicotine may also represent a gateway drug that leads to other addictive behaviors, including cigarette smoking

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