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The combination of cold, dry air, and smoke significantly increases throat irritation, potentially leading to long-term respiratory issues

The design of the cigarettes itself has undergone much more changes, although the image is still recognizable

Ireland, the UK) in all indicators, our analysis clearly illustrates the value of the more detailed indicators, as smoking intensity and duration differ considerably between EU countries

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Chromatin condensation evaluation: chromomycin A3 (CMA3) staining The CMA 3 staining was used to detect the abnormal protamination as described by Manicardi et al., 1995