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Pierce, Ph.D., the lead author of the study and the director of cancer prevention and control at the University of California San Diego's Moores Cancer Center

C., Parveen, M., Espinoza-Derout, J., Bautista, F., Razipour, M

Left: Annual PM2.5 map for the year 2021 (Wongnakae et al., 2023)

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Factors associated with cognitive impairment in COPD patients Cognitive impairment in COPD arises from a complex interplay of multiple factors, including inflammation, hypoxemia, hypercapnia, acute exacerbations, comorbidities (obstructive sleep apnoea, cerebral microbleeds, anxiety, and depression), and smoking ( Inflammation Chronic pulmonary inflammation in COPD disrupts the balance between immune system-mediated damage and repair mechanisms ( Hypoxemia and hypercapnia Alveolar hypoventilation in COPD frequently results in hypoxemia and hypercapnia, both of which contribute to cognitive decline ( Hypercapnia, often severe in advanced COPD (as indicated by higher GOLD stages), exerts deleterious effects on the central nervous system