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Cigarette smoke exposure HBE cells were exposed to mainstream smoke from 3R4F University of Kentucky reference cigarettes (Lexington, KY) using a VC-10 Smoking Robot (Vitrocell, Waldkirch, Germany) in accordance with ISO 3308 standards (puff duration 2 s, hold time 0 s, exhaust time 8 s, puff volume 35 mL, frequency 60 s, 6 puffs per cigarette)

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The phaseout of disposable vapes is stronger action than whats been seen in the U.S., where thousands of vapes are widely available even though the vast majority are technically illegal, as they have not received the regulatory authorization that any e-cigarettes for purchase are meant to have

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