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Cardiovascular pathophysiology: Nicotine and other components of smoke promote endothelial dysfunction, increase oxidative stress, and enhance platelet activation and coagulation, all of which accelerate atherosclerosis

Center for Disease Control estimated that $95 billion was spent on smoking-related disease each year from 2000-2004

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All tobacco products contain nicotine, including cigarettes, non-combusted cigarettescigars, smokeless tobaccohookah tobacco, and most e-cigarettes

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Heavy smokers have more than thrice the risk