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Using nicotine chronically will fundamentally rewire the brains natural ability to regulate stress, mood, or anxiety, and this creates a negative feedback loop that overall increases anxiety (3)

Sugawara, H

Women who smoked before pregnancy and quitted during each trimester of pregnancy still had an increased risk of congenital anomalies in offspring than women who did not smoke before and throughout pregnancy

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Preventive Services Task Force lowered the minimum age to start CT scans to age 50, down from 55

In a follow-up study, Gable 7 refined the approach and now provided a numerical safety ratio, which allowed a rank-ordering of abused substances