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The methodology was based on comparing the therapeutic index of the substances, which was defined as the ratio of the median lethal dose (LD50) to the median effective dose (ED50)

Sechenov First Moscow State Medical University, Moscow, Russia Vladimir Andreevich Korshunov, Platon D

Physical nicotine withdrawal typically peaks within the first 72 hours and largely resolves within 1 to 2 weeks

There, it is held for several minutes, enabling the smoker to really taste the various notes

Significant differences were observed between time points (F = 113.0 P 12mg/ml)

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