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Crosthwaite was most recently chief growth officer at Altria, and has worked in tobacco for more than 20 years

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In immortalised human bronchial epithelial cells with normal P53 and KRAS genes, which model normal airways, the high-nicotine medium generated using e-cigarette vapour was toxic, reducing cell growth and triggering cell death, but it did not cause the cells to develop cancerous behaviours, according to Park