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doi: 10.1056/NEJMra0910283 85 PalazonAGoldrathAWNizetVJohnsonRS

Vitamin B12 is found naturally in foods on animal origin, such as fish, meat, poultry, eggs and dairy

The renal susceptibility to crystal formation leads to various crystal nephropathies, primarily through CaOx-induced cytotoxicity in renal tubular epithelial cells

41 DrkendaP.SpahicA.Begic-AkagicA.GasiF.VranacA.HudinaM.et al

Fan et al., showed that tyrosine phosphorylation of JAM-A Y280 destabilized TJ-associated signalling elements, which resulted in decreased Rap2 GTPase activity and compromised epithelial barrier