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Once you have taken them for a while, you become tolerant to them, meaning it takes more of the drug to give you the desired feeling

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Opioids not only numb nerves but also activate the brains reward centers (which causes a sense of euphoria that can lead to addiction) and suppress respiration (which is why an overdose can be fatal)

Instead of being an early sign, bleeding may appear later, often alongside deeper periodontal pocket formation and connective tissue breakdown