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Five Topmost Addictive Substances in the World Nicotine vs. Cocaine: Which Substance is More Addictive? Cigarettes Are Highly Addictive What is Addiction? Zinnia Health Harvard researchers help explain link between emotion and addictive substance use Harvard Kennedy School Nicotine is highly addictive and affects both the brain and body. Whether it's vaping or smoking, nicotine can lead to dependence, cravings, and serious health risks over time. Understanding how nicotine works
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