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[8] There are two potential mechanisms by which reactive smoke components can produce their deleterious effects on essential plasma constituents: 1) indirectly, gas-phase cigarette smoke may activate macrophages and neutrophils in the lung, which may release enzymes and oxidants capable of damaging lipids and proteins

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This allows individuals to satisfy cravings while avoiding the toxins found in cigarette smoke

Association between initial use of e-cigarettes and subsequent cigarette smoking among adolescents and young adults