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For example, cinnamon flavor (cinnamaldehyde) is known to be cytotoxic to lung cells in vitro

We also know that menthol allows for greater cell permeability, meaning that menthol cigarette smoke will penetrate cells much more efficiently than if theres no menthol in it. Gardiner said that by deeply penetrating cells, menthol smoke can more effectively disrupt the function of lungs, kidneys, and heart leading to increased long-term chronic health problems and death

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Further reading "Electronic nicotine delivery systems" (PDF)

Ideal For: Fans of extra-cold, premium-style flavor who want a powerful, sharp cooling experience

They cant harm humans or pets, but they love tobacco, among other things