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At the same time, the agency has denied thousands of applicants, seemingly without bothering to fully review their applications, often justifying denials for applicants failing to include evidence that the FDA said they need not include or for seeking approval for non-tobacco flavors, despite there being no statutory, regulatory, or scientific rationale for the FDA to reject these applications without review

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The Bonferroni adjustment method was used for multiple comparisons

Chronic hives may be caused by infections, a problem with the immune system, or as result of other medical conditions such as lupus or other autoimmune conditions