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Among them, BMPR2 gene variation is the most important genetic inducement, which has been detected in more than 70% of familial PAH cases and approximately 15%-20% of sporadic IPAH cases, directly leading to BMPR2 protein synthesis disorder or functional deficiency and impairing the initial link of BMP signaling (Atkinson et al

Curiously, neither perceived vulnerability to COVID-19 nor change in smoking behavior was associated with respondents personal experiences with COVID-19

Smoking encourages the buildup of plaques containing various substances in the arteries, including cholesterol

This change again doubled the number of risk classes from 2 to 4 (male non-smoker, male smoker, female non-smoker, and female smoker)