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Nevertheless, both intravenous and vapor nicotine self-administration paradigms are valuable tools to investigate various aspects of nicotine dependence, and established protocols demonstrate blood levels of nicotines metabolites, cotinine, 5-hydroxycotinine and cotinine N-oxide, similar to that found in human smokers (60, 62, 65, 7274)

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RTs Three Key Takeaways: ntegrated Care Most Effective for Lung Cancer Screening Smoking Cessation:: Smokers receiving integrated care, including counseling and pharmacotherapy, had the highest quit rates, with nearly 32.4% remaining smoke-free at six months compared to 27.6% and 20.5% in other groups

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