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Whether this compositional shift translates to higher lung cancer risk remains unsettled: Conventional observational studies are inconsistent and rarely stratify by potency, but Mendelian randomization (MR) analyses suggest a possible causal signal for lung cancer (and specifically squamous histology) with genetic liability to cannabis use/use disorder (65,66)

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These symptoms can begin within hours of the last cigarette and peak within the first few days of cessation, although they can persist for weeks or even months in some cases

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Since her debut in 2005, she's gone on to become one of the best-selling artists of all time--with more than 250 million record sales worldwide