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Effect of nicotine on degranulation and [NO X ] in RBL-2H3, A549, NHTBE, and airway epithelial cells (AEC) In order to investigate whether nicotine, the major component of cigarette smoking in particulate phase, is responsible for the inhibition of degranulation and production of nitric oxide, RBL-2H3 cells were incubated in nicotine solutions (62.5250 M) adjusted to physiological pH for 24 h

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