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The mechanisms by which e-cigarettes cause these changes are not yet well understood, but they are likely related to the composition of the ingredients used in e-cigarette products and the harmful inhaled substances, such as carbonyls, volatile organic compounds, nicotine, trace metals, microbial toxins, and flavorings 33

Tobacco use costs national economies enormously through increased healthcare costs and decreased productivity

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For healthy nonsmoker ALI cultures, we found that Notch signaling strength was upregulated in ciliated4 upon ECE treatment but not upon CSE treatment (Fig

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