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130 It has been reported that the LIR domain in BCL2L13 selectively binds to GABARAP, GABARAP-L, and LC3C to promote mitophagy, while the Q277C/Q278I mutation in the LIR domain enhances its binding to LC3B, indicating that BCL2L13 can bind different LC3/GABARAP family proteins according to varying conditions during the induction of mitophagy

(59), showing high toxicity of CBs impacting survival, growth and reproduction