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Regardless of the consumption method, nicotine is primarily metabolized in the liver and excreted through the kidneys via urine, though cotinine can be detected in all major body fluids and hair

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The traditional report of the Chief Physician of the USA (Surgeon General) devoted to a smoking problem for 2006, contains the following facts: destructive impact of smoking on a human body surpasses such negative factors as a lack of physical activity (14%), alcohol intake (6%), various infections (5%), environmental pollution and poisonings (about 3%), use of firearms (about 2.7%), the road accidents (a little more than 1%) and the use of drugs (1%)