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Animal experiments show that this can inhibit the growth and repair of the lens of the eye.241 Studies with human volunteers illustrate that caffeines vasoconstrictive effect markedly reduces circulation to the macula, the central portion of the retina.242 Macular degeneration is the leading cause of vision loss and blind ness in people over sixty-five, with more than 16,000 new cases reported annually in the United States.243 Whats more, evidence suggests that the incidence of this condition is increasing rapidly.244 I find it remarkable that so little attention has been paid to the role of caffeine in eye health