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All current smokers were directed to make an appointment at smoking cessation clinics, which offer counselling as well as free cessation medications

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Studies both in macrophage cell lines and in alveolar and bronchial epithelial cells show that oxidants cause the release of inflammatory mediators (e.g., IL-8, IL-1, and NO) and that these events are associated with increased expression of the genes for these inflammatory mediators and with increased nuclear binding and activation of NF-B (Jimnez et al