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The risk of nicotine addiction associated with e-cigarette use makes it likely that e-cigarettes could serve as a gateway device to conventional tobacco smoking, the authors contend, and some research already supports this hypothesis

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Mean saccharin intake across the 8 d was 50.8 4.03 mg/kg for the nicotine-pretreated group and 50.3 5.09 mg/kg for the saline pretreated group (Fig