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Individuals who first tried marijuana before age 14 are at a higher risk for illicit drug dependence compared to those who start later, according to a 2021 report, Younger Age of First Cannabis Use or Prescription Drug Misuse is Associated with Faster Development of Substance Use Disorders published in the National Institute of Health

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Similarly strong inhibition was also observed for nornicotine formation in CYP2B6-overexpressing cell microsomes, with 1 and 10 M CBD exhibiting 75% and 85% inhibition, respectively, and 1 and 10 M 7-OH-CBD exhibiting 64% and 72% inhibition, respectively (Figure 3E)

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