e3 ubiquitin ligases mitophagy copd smoking or cigarette smoke Impaired in COPD. In regular conditions, smoke- Revisiting airway epithelial dysfunction and
Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: the role of mitochondrial damage American Journal of Physiology Lung Cellular and Molecular Physiology American Physiological Society PRKN Ser131 phosphorylation promotes cigarette smoke induced mitophagy impairment and epithelial cell senescence via MKK3 p38 MAPK activation: An in vitro and in vivo study Dysregulated autophagy in COPD: A pathogenic process to be deciphered ScienceDirect Full article: PRKN regulated mitophagy and cellular senescence during COPD pathogenesis MKK3 influences mitophagy and is involved in cigarette smoke induced inflammation ScienceDirect Ubiquitination and Acetylation in Cellular Senescence: Mechanisms, Crosstalk, and Therapeutic Implications Yu 2025 The FASEB Journal Wiley Online Library
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