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Tobacco 21 is a national campaign which seeks to raise the federal age limit for buying tobacco products to 21 years old instead of the nationally recognized 18 years old

All animal experiments were conducted in accordance with approved by the Institutional Animal Care and Use Committee at the University of Pittsburgh

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In the present study, downregulation of FoxA2 expression was accompanied by downregulation of E-cadherin expression in airway epithelial cells and in lung tissue of animals exposed to CS, further indicating that smoking results in abnormal differentiation of airway epithelial cells

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