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(PubMed) Bonaventura P, Benedetti G, Albarede F, Miossec P

Key Research Findings Much of this evidence comes from laboratory and animal research

Four families have not previously been reported and the three previously reported have not been reported as pathogenic or likely pathogenic according to ACMG guidelines

blue boxes, position of exons

The risk is thought to be higher for those undergoing treatment for strokes or traumatic brain injury, in which the generation of oxygen radicals may induce excessive brain activity

When cholesterol levels suffice, SREBP-2 is inactive and located in the endoplasmic reticulum (ER) associated with SREBP-2 cleavage activation protein (SCAP) [17]